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Trofosfamide-[d4] CAS NO.1189884-36-3
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Keywords
- N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-d4 2-Oxide
- Ixoten-d4
Quick Details
- ProName: Trofosfamide-[d4]
- CasNo: 1189884-36-3
- Molecular Formula: C9H14D4Cl3N2O2P
- Appearance: White Solid
- Application: For research use only.
- Purity: 95%
- Storage: Store at -20°C, Under Inert Atmosphere
- LimitNum: 0
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Details
Labelled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis.
