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Atazanavir-[d5] CAS NO.1132747-14-8
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- Product Details
Keywords
- 3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-dimethyl Ester (3S,8S,9S,12S)-2,5,6,13-Pentaazatetradecanedioic Acid-d5
- BMS-232632-d5
Quick Details
- ProName: Atazanavir-[d5]
- CasNo: 1132747-14-8
- Molecular Formula: C38H47D5N6O7
- Appearance: White to Off-white Solid
- Application: For research use only.
- Purity: > 98%
- Storage: -20°C
- LimitNum: 0
Superiority
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Details
Labelled Atazanavir. Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir.
