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Dxd-D5
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Keywords
- N-[(10S,23S)-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-10-(1,1,2,2,2-pentadeuterioethyl)-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl...
Quick Details
- ProName: Dxd-D5
- Molecular Formula: C26H19D5FN3O6
- Application: For research use only.
- Purity: 98.63%
- Storage: 4°C, sealed storage, away from moistur...
- LimitNum: 0
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Details
Dxd-D5 (Exatecan-D5 derivative for ADC) is a tritiated version of Dxd. Dxd is a potent DNA topoisomerase I inhibitor with IC50 of 0.31 μM, which can be used as a payload of an antibody drug-conjugated ADC (DS-8201a) targeting HER2.
