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Ribociclib cas 1211441-98-3 CAS NO.1211441-98-3
- Min.Order: 0 Metric Ton
- Payment Terms: L/C
- Product Details
Keywords
- 1211441-98-3
- Ribociclib
- cas 1211441-98-3
Quick Details
- ProName: Ribociclib cas 1211441-98-3
- CasNo: 1211441-98-3
- Molecular Formula: C23H30N8O
- Appearance: Yellow Solid
- Application: Inhibitor
- DeliveryTime: 7 days
- ProductionCapacity: 1 Kilogram/Month
- Purity: 98%
- LimitNum: 0 Metric Ton
Superiority
GMP factory
Packing with pallet as buyer's special request
Best service after shipment with e-mail
Cargos together with container sales seervice available
Api, inhibitor, and fine chemicals for more than 6 years.
Details
Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.